In the mid 20th century the prevailing theory of cancer as a problem of cell metabolism was discarded in favor of newly discovered DNA and the gene theory of cancer. More than half a century of work based on this hypothesis has shown little success relative to the effort expended. In recent years the metabolic theory of cancer has re-emerged and therapies based on this hypothesis have shown significant promise. We will talk about some of the basic science and clinical trials that support the theory that cancer is a metabolic disease and that we individually can take action to potentially prevent it as well as augment conventional treatment for it.